2,4-Difluorophenylboronic acid, CAS 144025-03-6, is an aryl boronic acid used as a fluorinated coupling partner in Suzuki–Miyaura reactions. It supplies a 2,4-difluorophenyl group for forming carbon–carbon bonds with aryl, heteroaryl, and selected vinyl halides under palladium-catalyzed conditions. Its listed molecular formula is C6H5BF2O2, with a molecular weight of approximately 157.93 g/mol. For B2B purchasing, I recommend evaluating identity, assay, water content, packaging, batch documentation, and supply continuity together rather than relying on the product name alone.
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This guide is intended for medicinal chemistry teams, pharmaceutical and agrochemical developers, custom synthesis organizations, research laboratories, and procurement professionals sourcing organic boronic acids. It is especially relevant when a project requires a defined fluorinated aryl fragment rather than an unsubstituted phenylboronic acid. The information is also useful for buyers preparing a request for quotation or comparing several specialty chemical suppliers.
My focus is not to prescribe one universal reaction recipe or to claim that every batch performs identically in every substrate system. Instead, I explain how I would assess this material for Suzuki coupling, which specifications deserve attention, and what information should be exchanged before a commercial order is placed. Final suitability should always be confirmed through the buyer’s own analytical and process-development procedures.
2,4-Difluorophenylboronic acid is an aromatic boronic acid containing a phenyl ring substituted with fluorine at the 2- and 4-positions and a boronic acid group at the remaining coupling position. In a Suzuki reaction, the boronic acid group participates in transmetalation with a palladium catalyst, followed by reductive elimination to form a new carbon–carbon bond. The fluorine atoms generally remain attached to the aromatic ring, allowing the resulting product to retain the intended fluorinated structure.
The compound is commonly represented by CAS 144025-03-6 and a molecular weight of approximately 157.93 g/mol. These identifiers are useful for initial procurement, but I recommend confirming them against the supplier’s certificate of analysis, safety data sheet, and product specification before material release. Buyers should also distinguish the free boronic acid from protected boronate forms because their handling, molecular weights, and reaction behavior can differ.
The primary use is the preparation of biaryl and heterobiaryl compounds through palladium-catalyzed Suzuki–Miyaura coupling. Typical electrophilic partners may include aryl bromides, aryl iodides, heteroaryl halides, and selected activated chlorides, although the best substrate and catalyst combination depends on the project. The product can be useful when a development program needs a fluorinated aromatic motif for structure–activity relationship studies or analog generation.
In medicinal chemistry, a fluorinated ring can be incorporated to explore changes in lipophilicity, metabolic behavior, conformation, or binding interactions. These effects are molecule-dependent, so I would treat fluorine substitution as a design variable rather than a guaranteed performance advantage. In process research, the material may also serve as a defined intermediate input for route evaluation, provided that impurity control and scale-up behavior are demonstrated for the specific reaction.
There is no single Suzuki coupling condition that is appropriate for every substrate. A reasonable laboratory screening plan may compare several palladium catalyst systems, bases, solvents, and temperatures, with an initial temperature window such as 50–100°C when compatible with the substrate and equipment. Reaction stoichiometry also requires optimization; using approximately 1.0–1.5 equivalents of boronic acid may be considered during method development, but the final amount should be based on conversion, selectivity, and process economics.
Water content, boronic acid stability, base selection, and the identity of the electrophile can influence reaction outcome. Some boronic acids may undergo oxidation, protodeboronation, or reduced reactivity under particular conditions, especially when the substrate or reaction medium is unsuitable. For that reason, I recommend using small-scale analytical screening before committing to a larger campaign.
The first review should confirm the product name, CAS number, molecular formula, molecular weight, appearance, and structural identity. A buyer may request chromatographic purity by HPLC or GC where appropriate, together with an assay method that is clearly defined. Because different analytical techniques measure different aspects of quality, a reported purity value should be interpreted alongside the method, chromatogram, and known impurity profile.
For many research and development projects, buyers may request an assay specification of 95% or higher as a starting procurement criterion, but the required limit should be set by the application, internal quality system, and downstream risk assessment. I do not recommend treating a generic purity threshold as proof of suitability for a demanding process. If the material is intended for a regulated or scale-up program, additional controls may be needed for residual solvents, elemental impurities, water, and trace metals.
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Ask the supplier to provide the expected physical form, net weight, packaging configuration, recommended storage conditions, and retest or review information when available. The packaging should protect the material from moisture, contamination, and repeated unnecessary exposure during laboratory use. For multi-batch programs, consistent container sizes and clear lot identification can simplify inventory control and traceability.
Useful documents may include a certificate of analysis, safety data sheet, technical data sheet, specification sheet, and shipment documentation. Buyers should check whether the documents are lot-specific and whether the analytical results correspond to the exact package being offered. If the project has special requirements, such as a maximum water limit or restricted solvent profile, those requirements should be agreed before production rather than after delivery.
I recommend beginning with a written specification request that includes the target quantity, intended use, required purity, packaging, delivery destination, and documentation needs. A capable supplier should be able to explain the available grade, analytical method, batch availability, and any known handling limitations without making unsupported performance promises. Technical responsiveness is particularly important when the buyer is comparing a catalog supply with a custom or repeat-production arrangement.
Supplier evaluation should include more than the quoted price per kilogram. Review whether the supplier can provide representative analytical data, maintain lot traceability, answer questions about storage and transport, and communicate changes in manufacturing or packaging. For export orders, confirm the commercial invoice details, packing list, safety documentation, customs information, and any destination-specific requirements before shipment.
MOQ and lead time depend on stock status, batch size, production scheduling, packaging, and destination. I recommend requesting both an in-stock option and a production option when the project may continue beyond the first order. A clear quotation should identify the validity period, available quantity, estimated dispatch time, shipping terms, and whether analytical release is included.
For early-stage research, a smaller package may reduce inventory risk and allow the buyer to confirm reaction performance. For repeated synthesis, buyers should consider reserving a consistent batch strategy or discussing forecast-based supply. The most useful comparison is total procurement risk, including delays, documentation gaps, repackaging, and the cost of qualifying a replacement source.
Another frequent issue is assuming that a fluorinated boronic acid can be substituted directly for a different arylboronic acid without reaction re-optimization. Electronic effects, steric effects, catalyst compatibility, and the halide partner can all change the practical conversion and selectivity. I therefore suggest retaining a small development quantity for screening even when the final commercial route is already defined.
At Maison Chemical, I support B2B buyers evaluating 2,4-Difluorophenylboronic acid CAS 144025-03-6 for research, development, and manufacturing-related applications. We can discuss the requested quantity, grade expectations, packaging, specification items, documentation, and destination requirements before quotation. Where a project has defined limits for assay, water, residual solvents, or delivery timing, those details should be included in the initial inquiry so that the proposed supply can be assessed accurately.
Our role is to provide practical communication between the buyer’s technical, procurement, and logistics teams. We do not present a universal reaction result or an absolute delivery guarantee without reviewing the specific order conditions. Instead, we aim to clarify available supply, provide relevant batch documentation, and help buyers determine whether the offered material matches their application and quality system.
2,4-Difluorophenylboronic acid CAS 144025-03-6 is a relevant fluorinated aryl building block for Suzuki coupling when a synthesis requires the 2,4-difluorophenyl structure. The most reliable purchasing decision combines chemical identity, analytical quality, physical handling information, supply continuity, and supplier responsiveness. Price alone is not sufficient to judge whether a specialty boronic acid is suitable for a development or production program.
Before placing an order, send Maison Chemical your required quantity, target specification, intended grade, packaging preference, destination, and documentation list. If the reaction is still under development, indicate the electrophile class and approximate project stage so that the supply discussion is aligned with your actual need. Requesting a quotation together with lot-specific analytical information is the practical next step toward evaluating 2,4-Difluorophenylboronic acid for your Suzuki coupling program.
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