Phenylboronic acid, identified by CAS 98-80-6, is an organoboron compound used primarily as a building block and coupling partner in organic synthesis. Its phenyl group is bonded to a boronic acid group, giving the molecule the formula C6H7BO2 and a molecular weight of 121.93 g/mol. Researchers and manufacturers commonly use it in palladium-catalyzed Suzuki–Miyaura cross-coupling to form carbon–carbon bonds. For buyers, the key considerations are the required purity, intended reaction conditions, documentation, packaging, and consistency between batches.
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Phenylboronic acid is a boronic acid in which a phenyl ring is attached to a boron atom bearing two hydroxyl groups. The boronic acid functionality can participate in chemical transformations that transfer the phenyl group to another molecular fragment. This reactivity makes the compound useful in laboratory research, process development, and the preparation of more complex organic molecules. It is generally supplied as a solid, but exact appearance and handling details should be checked against the current product specification and safety data sheet.
The CAS Registry Number 98-80-6 identifies phenylboronic acid, while its molecular formula is C6H7BO2. Its molecular weight is 121.93 g/mol, a practical value for calculating molar quantities during reaction planning. A commonly reported melting range is approximately 216–219 °C, although measured results can depend on the test method, sample condition, and product specification. Buyers should treat reference values as guidance and use the supplier’s lot-specific documentation for acceptance decisions.
| Property | Reference information | Buyer consideration |
|---|---|---|
| CAS number | 98-80-6 | Use to confirm chemical identity when requesting a quote or reviewing documents. |
| Molecular formula | C6H7BO2 | Check that the formula matches the intended reagent and reaction calculations. |
| Molecular weight | 121.93 g/mol | Use for theoretical stoichiometry; confirm purity when calculating actual charge quantities. |
| Melting range | Commonly reported around 216–219 °C | Compare with the current lot specification and stated test method. |
The defining synthetic role of phenylboronic acid is as a phenyl donor in carbon–carbon bond-forming reactions. In Suzuki–Miyaura coupling, it reacts with an organic halide or a related electrophilic partner in the presence of a suitable catalyst and reaction system. The product can be a biaryl or another compound containing a newly formed carbon–carbon bond, depending on the coupling partner. Reaction performance is not determined by the boronic acid alone; catalyst choice, solvent, base, temperature, and substrate structure also matter.
Phenylboronic acid can support the preparation of substituted aromatic compounds used in medicinal chemistry research, materials development, and other organic synthesis programs. It may be selected when a synthesis route calls for introducing a phenyl group at a specific stage. It is also useful in route scouting because boronic acids are established coupling partners across many research workflows. Whether it is appropriate for a production process should be determined through route-specific development and scale-up assessment.
Boronic acids can reversibly interact with certain compounds containing adjacent hydroxyl groups, including diol structures, under suitable conditions. This general behavior is relevant to molecular recognition research and the design of boron-containing chemical systems. The strength and usefulness of an interaction depend on factors such as pH, solvent, molecular structure, and experimental conditions. Buyers should therefore distinguish this broader boronic-acid chemistry from the more common use of phenylboronic acid as a coupling reagent.
In pharmaceutical and fine-chemical research, phenylboronic acid may serve as an intermediate for synthesizing aromatic structures during discovery or process-development work. Its application is route-dependent: the desired target, available coupling partner, and reaction compatibility determine whether it is a good fit. It can also be used in academic and industrial laboratories exploring catalytic methods or preparing reference compounds. These examples describe general chemical uses and do not imply approval for a particular regulated application.
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Phenylboronic acid is a defined chemical identity, but products offered by different suppliers may vary in stated purity, test methods, packaging, and documentation. Some vendors may list research or industrial options, while the precise grade terminology and availability differ by supplier. Do not assume that a grade name guarantees suitability for a specific synthesis or regulated process. Instead, communicate the intended use and compare the actual specification and supporting documents.
Start by matching the product specification to the requirements of the reaction or manufacturing step. Purity can affect reaction outcomes and material usage, but a higher stated assay is not automatically the best commercial choice if other critical attributes are not controlled. Review the test method, acceptance limits, and lot documentation, and ask how changes to the specification are communicated. For development work, consider whether the supplier can discuss sample quantities and subsequent scale requirements before you begin evaluation.
Beyond price, buyers should assess response quality, document readiness, supply format, and the supplier’s ability to clarify technical requirements. Ask for a current specification and representative documentation before placing an order, and confirm that the quoted product is specifically phenylboronic acid, CAS 98-80-6. For repeat purchases, establish how batch-to-batch consistency is documented and how any deviations are handled. These checks help align procurement decisions with laboratory, quality, and logistics needs without assuming that all suppliers offer identical controls.
At Maison Chemical, we support B2B inquiries for phenylboronic acid by clarifying the requested grade, quantity, packaging, and documentation needs. We can review your stated specification requirements and confirm the available product information, commercial options, and shipment details for your inquiry. Availability, lead time, and documentation should be confirmed for the specific order rather than assumed from general product information. Sharing your target quantity, destination, and any required specification limits helps us provide a more relevant quotation.
Phenylboronic acid CAS 98-80-6 is an aromatic boronic acid best known as a synthetic intermediate and phenyl donor in Suzuki–Miyaura coupling. Its molecular weight is 121.93 g/mol, and a commonly cited melting range is approximately 216–219 °C, but buyers should verify reference values against the offered lot’s specification. It may be relevant when your route requires phenyl-group transfer or other boronic-acid chemistry, provided the reaction conditions and product requirements are compatible.
To move forward, define your intended application, required purity and impurity limits, quantity, and documentation needs. Then compare the supplier’s current specification, COA availability, packaging options, and confirmed lead time. Contact Maison Chemical with these details to discuss product availability and request a quotation for your phenylboronic acid requirement.
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